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While some studies found no difference between individuals with T2DM and matched non-diabetic controls (6769), others found plasma DPP-4 activity to be reduced in the patients, and suggested this might reflect a compensatory response to the reduced insulin sensitivity and hyperglycaemia, in an attempt to increase intact incretin hormone concentrations and improve insulin secretion (70, 71)

This increase reflects a pattern of growing use of newer GLP-1s, such as Ozempic and Mounjaro, while use of older products, such as Byetta (approved in 2005), Victoza (approved in 2010), and Trulicity (approved in 2014), has declined

The link between kidney stones and inflammation has garnered increasing attention [4, 53]

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The PCAC meeting, including testimony from key opinion leaders, physicians, and pharmacists, did not create these expectations