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A study of cerebral ischemia discovered that chlorogenic acid modulated the Nrf2 pathway and enhanced the expression of Nrf2, HO-1, and NQO-1 to counteract the reperfusion-induced brain injury that caused brain ischemia (Liu et al., 2020)

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Moreover, AEA and delta-9-THC stimulate COX-2 expression, which increases the synthesis of metalloproteinases 1, 3, and 9, as well as prostaglandin E2 (PGE2)

The gut microbiome also plays a central role in modulating glutathione homeostasis, as microbial metabolites influence cysteine availability, redox signaling, and antioxidant enzyme expression, linking dietary patterns to systemic redox and cardiometabolic health (24)