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Intranasal administration of exendin-4 antagonizes Abeta31-35-induced disruption of circadian rhythm and impairment of learning and memory

The requirement for hospitalization and mechanical ventilation in patients with severe COVID-19 (mostly in high-risk groups, such as elderly individuals or those with comorbidities) caused acute strains on healthcare systems at the peak of the pandemic, thus leading to national lockdowns and vaccination programs

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The peptides were transported from the surface of the olfactory bulb or bottom region of the brain around the hypothalamus to the deeper part of the brain through the CSF or perivascular spaces of the cerebral artery (Kamei et al., 2021)