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High-dose B12, particularly intramuscular injections delivering 1,000 micrograms or more, appears more likely to trigger acne than standard dietary intake or lower-dose oral supplements

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With sufficient glutathione present, NAPQI is very quickly metabolized into sulfate and cysteine compounds, which are readily excreted through the kidneys.[ref] However, when it isnt neutralized, NAPQI is highly reactive and can cause oxidative stress and damage to the liver cells, hepatocytes, leading to cell death

1 Effect Allele: TC (+/-) You have the TC genotype for rs6265, which means you carry one copy of the effect allele and one copy of the non-effect allele