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By integrating genetics into the initial telehealth consultation, PlexusDx shortens the pathway to effective therapy, meaning uninsured patients reach their target weight in fewer months and lower cumulative cost than empirical dose-escalation alone

Mechanistically, SYVN1 binds to HMGB1, promoting its ubiquitination and degradation and alleviating SCIRI in rats by downregulating HMGB1 and activating the Nrf2/HO-1 pathway

In part, that's because neurologically it's a fairly simple pathway