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Unlike semaglutide, tirzepatide tackles obesity from two fronts

Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice

By stabilizing energy levels, semaglutide helps break the cycle of sugar dependence that fuels afternoon cravings and late-night snacking

1 Tirzepatide 15 mg: -11.2 kg average weight loss Injectable semaglutide 1 mg: -5.7 kg average weight loss HbA1c: -2.30% with tirzepatide 15 mg vs -1.86% with semaglutide 1 mg Rybelsus 14 mg (the highest available oral dose) produces roughly equivalent blood levels to injectable semaglutide 0.5-1.0 mg per week, which is at or below the injectable dose tested in SURPASS-2

These shifts may impact the menstrual cycle or trigger breakthrough bleeding, especially in premenopausal women or those with underlying hormonal imbalances