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Thank you to our sponsors AG1 (Athletic Greens): InsideTracker: Thesis: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Introduction (00:06:20) Nerves and Muscles (00:12:00) Exercise alone wont change your brain (00:12:58) Behavior will change your brain (00:13:30) Remembering the wrong things (00:15:00) Behavior as the gate to plasticity (00:15:45) Types of Plasticity (00:17:32) Errors Not Flow Trigger Plasticity (00:21:30) Mechanisms of Plasticity (00:22:30) What to learn when you are young (00:23:50) Alignment of your brain maps: neuron sandwiches 00:26:00: Wearing Prisms On Your Face (00:29:10) The KEY Trigger Plasticity (00:32:20) Frustration Is the Feeling to Follow (Further into Learning) (00:33:10) Incremental Learning (00:35:30) Huberman Free Throws (00:38:50) Failure Specificity Triggers Specific Plastic Changes (00:40:20) Triggering Rapid, Massive Plasticity Made Possible (00:43:25) Addiction (00:45:25) An Example of Ultradian-Incremental Learning 00:49:42: Bad Events (00:51:55) Surprise

Adam Plitt, executive chef for Delmonicos Hospitality Group, believes that the rise of GLP-1s will not curb people dining out, even if they consume smaller portions
SGLT2i receivers exhibited a 23 mmol/mol drop in HbA1c, and GLP1-RA recipients showed an 18 mmol/mol decrease in HbA1c of 6,856 individuals (8.0%), with an estimated HbA1c advantage on SGLT2 inhibitors of 5.0 mmol/mol
AbbVies global Humira revenues did fall: the company reported a 41 percent year-over-year drop in Q4 2023 revenues for the product