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Prior to reinstatement test sessions, the GLP-1R antagonist exendin-(9-39) (10 g/100nl) was infused directly into the VTA 10 minutes before administration of CNO (1.0 mg/kg, i.p.) to determine if pharmacological inhibition of VTA GLP-1Rs is sufficient to block the suppressive effects of chemogenetic activation of NTSVTA projections on cocaine seeking (Fig 3D)