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Black caregivers of people living with dementia are also more likely to provide help with ADLs than White caregivers of people living with or without dementia

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By disrupting the interaction between FOXO4 and p53, FOXO4-DRI induces apoptosis (programmed cell death) in senescent cells, reducing their harmful effects

EM and SG helped with obtaining in vivo samples and processing

As has been the case in oncology (see Box 4-1), the ability to subtype individuals based on distinct biological mechanisms will likely be key to effective prevention and treatment of AD/ADRD and requires continued investment in multiomics studies and advancing neuroimaging capabilities and the identification of diverse fluid-based biomarkers that can be developed into multiplexed panels