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In humans, GPx1 is one (of many) selenoprotein(s) that may play a role in Keshan disease, a cardiomyopathy which is found in areas of China with low selenium levels [23]

Response: We appreciate commenters' feedback regarding the use of objective pain data and databases for measurement in the ASM low back pain cohort

It does not specifically modulate delta sleep architecture to the degree DSIP does

This commenter also stated their belief that CMS should cover the costs of survey administration to avoid shifting financial responsibility onto physician practices

Its compounding status is shifting, and a federal compounding advisory review is scheduled for July 2026 to weigh whether licensed pharmacies can prepare it