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They are not authorized as prescription drugs, and their sale for human use is typically restricted

SURMOUNT did so for tirzepatide (NEJM, 2022)

Mechanism of Action (MOA) Normally, Levodopa is broken down in the periphery by: DOPA decarboxylase COMT enzyme Entacapone inhibits COMT enzyme in peripheral tissues, which prevents conversion of Levodopa into 3-O-methyldopa (inactive metabolite)

An active site is the part of an enzyme that directly binds to a substrate and carries out a reaction

It is also not known whether Bacteriostatic Water for Injection containing additives can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity