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The decreased in GFR or albuminuria has been associated with the presence of nonalcoholic steatohepatitis or the severity of fibrosis, whereas improvement in liver histology is associated with improvement in CKD.75 arGLP1 improves insulin levels, regulates autophagy, inhibits hepatic neoglycogenesis, reduces hepatic fat content, plasma liver enzyme levels and hepatic histological improvements have been described with liraglutide and semaglutide.49,76 Likewise, epicardial and perirenal fat are associated with increased cardiorenal risk,77 so that the reduction in ectopic fat43 as demonstrated with the use of arGLP-1 has could be beneficial in CKD

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It was first created to help people with type 2 diabetes manage blood sugar, but it quickly became popular for its strong weight loss benefits

Authors contributions Both authors contributed equally as far as the conception of the article is concerned

Compounded tesamorelin used for body composition and visceral fat reduction is an off-label application and is not covered by insurance