Studies show that women can gain an average of 5-10 pounds during this time, with some experiencing more depending on their baseline body weight, genetics, and lifestyle factors
384,385,386 Moreover, LDH PROteolysis TArgeting Chimeras (PROTAC) degrader, MS6105, time and ubiquitin-proteasome system-dependently degrades LDHA/B and inhibits the proliferation in multiple pancreatic cancer cell lines
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This is concerning because loss of skeletal muscle can lead to decreased strength, reduced functional capacity, and a lower resting metabolic rate, potentially making weight regain more likely after medication discontinuation
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