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Drug shortages during the study period may also have influenced treatment patterns
54 Early observational studies raised concerns regarding a potential association between GLP-1 RA therapy and pancreatitis
Mechanism of Action Retatrutides multi-receptor activation leads to: Strong suppression of appetite and food intake (GLP-1 & GIP pathways) Enhanced insulin secretion and glucose control Potential increases in energy expenditure and fat oxidation (glucagon agonism, which may uniquely drive liver fat reduction) Early studies suggest additive benefits beyond tirzepatide or semaglutide, but full long-term data are pending
Ann N Y Acad Sci 1478(1):317
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