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The supernatant (serum) was carefully collected and stored at 80C until analysis

Testosterone therapy: what we have learned from trials

At high doses, niacin can affect liver enzymes and blood sugar levels

Additional safety concerns include increased fall risk, particularly in older adults, memory impairment and cognitive effects, potential for overdose, especially when combined with alcohol or other depressants, and increased risk of motor vehicle accidents due to impaired reaction time and coordination

Our approach: Start low, go slow: Begin with the lowest effective dose Titrate every 4 weeks, only if tolerated Monitor for side effects at every visit Evaluate efficacy at 36 months For population health leaders, thoughtful prescribing: -Reduces complications from uncontrolled metabolic conditions -Lowers medication waste -Drives down long-term healthcare spend When used with intention, GLP-1s and, most importantly, coming off of them after building metabolic resilience, can help people reclaim agency over their health long-term