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First, almost every included study did not consider thyroid events as the main result, only regarded them as safety results and did not monitor the changes in thyroid function at the same time

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Semaglutide injection focuses primarily on GLP-1 pathways, regulating appetite and slowing digestion Tirzepatide targets both GLP-1 and GIP receptors, offering a broader metabolic effect Tirzepatide may produce more pronounced weight loss in some individuals Semaglutide is often used as a starting point or for steady, controlled progress The choice between the two depends on individual goals, metabolic profile, and response to treatment

The most frequently reported issues include: Nausea : Nausea is one of the most common side effects of semaglutide, especially when starting treatment or increasing the dosage

10.1111/jne.12488 72 KinneyJ