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An internal medicine physician on Sermo captured this measured approach, A drug like retatrutide has the potential to be a real breakthrough

DPP-4 Inhibitors In addition to their glucose-lowering effects, potential mechanisms for dipeptidyl peptidase-4 (DPP-4) inhibitors CV effect include increased ischemia tolerance, improved endothelial function, decreased expression of inflammatory cytokines, and decreased platelet aggregation

DFS Results iCRT arm: 68.3% at 3 years

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Finally, a 26-week, double-blind trial evaluated the efficacy and safety of ertugliflozin in T2DM patients who were inadequately controlled (HbA1c, 7.010.5%) after a minimum of 8 weeks of metformin therapy ( 1500 mg/day) [55]