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In conclusion, gene regulation is increasingly recognized as a key determinant of meningococcal virulence

These DAMPs activate pattern recognition receptors (PRRs), notably TLR4 and RAGE (receptor for advanced glycation end products) on neighboring epithelial cells, infiltrating neutrophils, macrophages, and resident fibroblasts (95, 96)

Yu Y, Jin L, Zhuang Y, Hu Y, Cang J, Guo K