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Mistake 4: Ignoring the importance of cycling The recommended protocol of 2 months on, 2 months off exists for good reason

Importantly, comparisons between male and female mice indicate that metformin may have a more significant positive impact on cognitive function in females, highlighting the importance of sex as a key factor in determining the drug's therapeutic benefits (181)

Nickson D, et al

Patients with glutathione synthetase deficiency accumulate the dipeptide -glutamylcysteine and cysteine in fibroblasts [24]

In contrast, platelet-rich plasma (PRP) therapy has emerged as a regenerative treatment that enhances cartilage repair, reduces inflammation, and slows OA progression