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1, 2, 3 These receptors have increasing clinical importance as, on one hand, they mediate the action of commercially available GLP1 analogs such as exenatide or liraglutide to help treat diabetes patients 4, 5, 6 and, on the other hand, represent the targets for radiolabeled GLP1 or exendin to visualize in vivo insulinoma tumors
183 These findings indicate that small molecule agonists activate or modulate the GLP-1R in a manner that is distinct from that of GLP-1
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Central nervous system effects: The ability of SLU-PP-332 to cross the blood-brain barrier more readily may make it a better candidate for neurological indications