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Clinical trial data from the SUSTAIN and STEP programs indicate that nausea, the most frequently reported side effect, generally improves within 46 weeks for most patients as tolerance develops

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Kurkowska-Jastrzebska I, Wronska A, Kohutnicka M, Czlonkowski A, Czlonkowska A

Many Seattle patients report meaningful appetite reduction within 23 weeks and measurable weight loss by week 8