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Indeed, the development of single-cell RNA sequencing analyses has led to the detection of microglial heterogeneity in both physiological and pathological conditions, suggesting that microglial activation is a dynamic response involving transcriptionally and spatially different subpopulations (Keren-Shaul et al., 2017

Two hours post-surgery, mice were administered treatments via caudal vein injection

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Overall, the rate of surgery-related opioid prescriptions dropped by 36% from 2016 to the end of 2022, and the average amount of opioids in those prescriptions dropped by 46%, the study of pharmacy data finds