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276 Pathological prion instigates neuronal death, which in turn causes secondary astrocytic reactivity predominantly in the white matter, but the roles of reactive astroglia in prion diseases are poorly understood and hampered by the emerging complexity of astrocyte responses to prion induced pathologies

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For CJC-1295, the same logic applies with the compounds own reconstitution

245 In human astrocytes neurotropic flaviviruses increase autophagy, although viral replication is autophagy-independent