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Disruption of its function has been identified in several neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and prion diseases, as well as in amyotrophic lateral sclerosis (ALS)

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Alcohol and Vitamin B Deficiency Long-term heavy drinking can lead to a deficiency in vitamin B1 (thiamine) , increasing the risk of developing conditions like Wernicke-Korsakoff syndrome , a serious neurological disorder