Under resting conditions, ASC is S-glutathionylated (notably at Cys171), a modification that impairs ASC oligomerization and prevents spontaneous inflammasome formation 67
The kidney, in turn, maintains brain function by regulating blood volume, pressure, and levels of electrolytes, such as sodium, potassium, and chloride, which are essential for nerve and muscle function, including those in the brain (Dalal et al., 2024)
Adelstein SJ, Vallee BL (1961) Copper metabolism in man
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