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In fibroblast-like RA synoviocytes, the administration of lixisenatide resulted in a reduction in the inflammatory response

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FDA staff briefing documents ahead of the meeting recommended against adding all seven peptides, pointing to limited characterization data, sparse or low-quality human clinical evidence, and unanswered safety questions (including immunogenicity risks for some routes of administration)

Invest Ophthalmol Visual Sci (2011) 52(5):2696703