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Signaling mediated by these receptors leads to the activation of Rac1, a GTPase of the RHO family, which regulates the polymerization and reorganization of the actin cytoskeleton in phagocytes, facilitating the formation of the phagocytic cup, the internalization of the apoptotic body and the formation of the phagosome - in a process mediated by the protein complexes LRP1-GULP and ELMO-DOCK, responsible for the activation of Rac1 [12, 13]

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We did detect mild staining around the mouth and nose of one rat treated with 50 nmol/kg/day GEP44 and one additional rat when treated with a single 100 nmol/kg dose of GEP44