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In native biological systems, endogenous amylin is co-secreted with insulin by pancreatic beta cells but possesses an exceptionally brief experimental half-life, subject to rapid renal clearance

The compounds require injection, and access can be limited due to cost and shortages

Novo Nordisk A/Ss weight-loss medications are under investigation by the European Unions drug regulator after reports of suicidal risks were referred to it

Important note for women of childbearing potential : Tirzepatide can reduce the exposure to oral contraceptives, particularly during initiation and after dose increases