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A thiol bond is formed between the glutathione and an alipathic spacer that is linked to a hydroxyl group on the surface of the agarose bead [7]

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Determination of N-acetylcysteine in human plasma by gas chromatographymass spectrometry

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it was early recognised that APAP was hepatotoxic at high doses3 but that there were marked species differences in sensitivity.4 Further, these early studies established that a metabolite of APAP, rather than the drug itself, was the cause of its hepatotoxicity

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