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A phase III clinical trial examining lapatinib, a dual EGFR/HER-2 tyrosine kinase inhibitor that inhibits the EGFR/HER-2 signaling pathway, has shown that lapatinib reverses resistance to trastuzumab in patients with breast cancer with trastuzumab resistance 86 ( Table 1 )

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Clin Colorectal Cancer 17(1):3240 Mathew B, Sankaranarayanan R, Nair PP, Varghese C, Somanathan T, Amma BP et al (1995) Evaluation of chemoprevention of oral cancer with Spirulina fusiformis