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Genome-wide activation screening identified that GCH1 and its metabolites BH 4 /BH 2 (dihydrobiopterin) inhibit ferroptosis via lipid remodeling, specifically by selectively protecting phospholipids containing two polyunsaturated fatty acyl chains and enhancing the reduced state of CoQ 10 (28)

This setup resulted in a marked reduction in IFN production and CD44 expression by Th1 cells, compared to cultures without eosinophils (Figs