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At 10 nmol/l Ex-4 inhibits IB-phosphorylation and prevents NF-B/p65 nuclear translocation, halving tumor necrosis factor alpha (TNF-) and IL-6 both intracellularly and in the medium [19], thereby attenuating pro-inflammatory signaling and enhancing hMSC viability under inflammatory conditions

Chronic systemic inflammation, a consequence of diabetes, can exacerbate neuroinflammation, which is implicated in the pathogenesis of PD

Some studies have found that vitamin B 12 deficiency is associated with obesity