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Daher B, Parks SK, Durivault J et al (2019) Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival, and tumor formation via nutrient and oxidative stresses

Looking ahead, we see advanced HILIC-based methods playing an increasingly crucial role in analyzing highly polar peptides and their impurities, which can be difficult to separate using conventional reversed-phase LC

Besides the amyloidogenic proteins, several other proteins have also been shown to be able to punch holes in mitochondria through interaction with cardiolipin, including members of the Bcl-2 family, cobra venom cardiotoxins and bacterial toxins ( Pyroptosis is a cell death program that involves disruption of the plasma membrane and the release of pro-inflammatory cytokines into the external milieu

To denature the proteins, 120 L of 8 M urea in 50 mM Tris-HCl (pH 8) was added