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The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

Ecnoglutide may become an important regional competitor, particularly in China, but global head-to-head data against semaglutide would be needed to establish clinical superiority based on its biased signaling profile

Together, these data highlight the therapeutic potential of incretin receptor agonism in slowing or reversing liver fibrosis, while emphasising the need for further mechanistic studies in human-relevant systems to delineate direct versus indirect effects fully