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This is one reason why high-fiber diets are associated with better metabolic health, a connection that has been documented in countless epidemiological studies

Regular review appointments during the first few months of GLP-1 treatment are advisable for patients with pre-existing IBS to ensure both conditions are optimally managed and to maintain quality of life

24,25 In leptin-resistant obese models, the co-administration of amylin analogs restored leptin sensitivity and potentiated weight loss, demonstrating a synergistic effect (Fig

Furthermore, the activation of GLP-1R signaling in the ventromedial hypothalamus (VMH) can also control energy expenditure by promoting food intake-independent weight loss by inducing brown adipose tissue (BAT) thermogenesis and browning through a sympathetic drive to BAT [6]

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