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The most important difference between naltrexone and GLP-1s may be less about their pharmacological properties than about how we understand them socially

The peptide is constructed on a GIP receptor backbone with non-coded amino acid residues (Aib2, Aib20, aMeL13) and a C20 fatty diacid moiety that enables albumin binding, extending pharmacokinetic half-life for once-weekly administration in research settings