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In some embodiments, the otoprotectant is any one of the following compounds: In some embodiments, the otoprotectant is a compound comprising a thiophene-carboxamide moiety core structure of Formula (I): In some embodiments, the otoprotectant is a compound comprising a thiophene-carboxamide moiety core structure of Formula (II): wherein ring A is optionally attached and is a 5-7 membered ring that is aromatic or non-aromatic and can contain one more heteroatoms (N, O, or S atoms)

Wu Q, Xia Y, Dai K, Bai P, Kwan KKL, Guo MSS

CHAC1 (cation transport regulator homologue 1) was one of the most significantly upregulated genes in response to GSTO1 knockdown (Supplementary Table 10)

Additionally, CLA enhances the immune systems anti-infective capacity by regulating macrophage activity and differentiation and inhibiting excessive reactive oxygen species (ROS) synthesis (100)