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Another study in colonic-sensitized rat models demonstrated that exendin-4 treatment dose-dependently reduced visceral hypersensitivity by upregulating serotonin transporter (SERT) expression and downregulating tryptophan hydroxylase-1 (TPH-1) expression [57]

Chetna Bakshi, a bariatric surgeon at Northwell Healths Syosset Hospital in New York, told AARP that adding a pill to the mix could offer more options for those patients who are unable to do the injections. It could also be a preferable choice for people who travel frequently, since the injectable medications require refrigeration

There is now a pressing need for data collection, and many important scientific questions that still need to be addressed

References Renal tubular effects of prolonged therapy with the GLP-1 receptor agonist lixisenatide in patients with type 2 diabetes mellitus