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It is required for pyrimidine nucleoside biosynthesis and has been implicated in the inhibition of apoptosis by preventing the collapse of the inner mitochondrial membrane [63]
Moreover, the translation of human genetic and preclinical findings in ASD can provide mechanistic insights and clues to rescue different behavioral and synaptic deficits in early preclinical models, which may serve as a basis for future clinical trials
10.1038/s41598-022-11819-z 152
A report from the EMAs PRAC, published on 12 April 2024, said: After reviewing the available evidence from non-clinical studies, clinical trials, post-marketing surveillance data and the available studies the PRAC considers that no update to the product information is warranted. The PRAC statement said that market authorisation holders would continue to monitor events, including new studies, as part of their pharmacovigilance activities