Metformin and GLP-1 receptor agonists are two separate medication classes that address metabolic health in fundamentally different ways
RDs play a central role in this process, providing MNT that evolves based on the patients clinical response, dietary intake, muscle mass, and tolerance to medication.50,51 Before initiating GLP-1 therapy, clinicians should assess baseline diet, medical conditions, disordered eating patterns, and social determinants of health to identify barriers and tailor care.19 Ongoing monitoring should include changes in weight, muscle strength, and nutrient intake, using flexible care delivery models such as telehealth, group visits, or Food is Medicine programs to improve access and equity to nutrient dense foods.19 MNT Recommendations To support long-term success, lifestyle interventions must be structured and ongoing
66,67 Furthermore, oxidative stress disrupts mitochondrial membrane potential, impairs autophagy, and induces apoptosis, contributing to progressive liver damage
Stop drinking immediately
Most patients tolerate restarting at their regular dose without complications, though some experience mild nausea as the medication's appetite-suppressing effects return
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