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Major modifications for 2025 As outlined in the 2025 Summary of Major Modifications and Explanatory Notes, the major modifications for 2025 include the following: Further examples were added to the following substance classes to help athletes and their entourage better identify prohibited substances: S0

The observed downregulation of muscle atrophy-related ubiquitin ligases (Atrogin-1 and MuRF-1) is consistent with the reported capacity of SCFAs to modulate proteolytic pathways 56 , thereby potentially contributing to the amelioration of muscle metabolic dysfunction

Glutathione comes in a few different forms, and its good to be aware of how these different forms are used in different applications

Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells

Rosemary stimulates circulation, ensuring nutrients reach the follicle to maximize peptide performance