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Temperature cycling, repeatedly moving between refrigerator and room temperature, accelerates degradation beyond what either constant temperature would cause

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A standard initial course is typically 6 sessions, spaced 12 weeks apart

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-Synuclein aggregates exhibit prion-like characteristics and when insoluble -synuclein fibrils are injected into the brains of animals, this pathology can template soluble -synuclein and thereby spread to other brain regions [15, 16]