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In addition to elevated CRP, IL-6, and TNF-, shift workers show altered immune profiles such as a reduced CD4 + /CD8 + T-cell ratio, increased monocyte counts, and impaired NK cell cytotoxicity

Some combine it with vitamin C and other antioxidants

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Lifestyle factors including chronic stress, inadequate sleep, excessive alcohol consumption, intense exercise without adequate recovery, and chronic infections also deplete glutathione reserves faster than the body can replenish them through endogenous synthesis

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