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As predicted in silico, the addition of relatively small, lipophilic groups to the meta position of the ring maintained or slightly improved affinity when measured by the R2KD assay (Table 2)

The pattern of results, particularly the amplification of benefit at higher weight loss thresholds, is consistent with the hypothesis that HRT restores a metabolic environment that makes GLP-1 therapy more effective: improving insulin sensitivity, preserving lean mass, reducing the inflammatory burden that blunts metabolic responsiveness, and supporting the mitochondrial function that underlies energy regulation

[DOI] [PubMed] [Google Scholar] 37.Jourkesh M, Ostojic SM, Azarbayjani MA