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Whole-body insulin sensitivity (assessed by the Matsuda index) did not differ between the four study days

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Still, this evidence was not confirmed in the CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) trial, which evaluated canagliflozin in patients with DM and chronic kidney disease, and was further averted by a pooled analysis of CANVAS and CREDENCE, which showed no increased risk of MALE with canagliflozin and its greater benefits in patients with PAD