The maximum recommended dose for adults is 4 grams (4,000 mg) per day, divided into doses of 5001,000 mg every 46 hours, with no more than four doses in 24 hours
For example, a 2013 trial found it significantly improved menopause symptoms across multiple categories, including vasomotor, physical, and psychological measures.62 While its primarily studied for menopause, theres some evidence suggesting it may also help with PMS-related discomfort.53 Chasteberry (Vitex) Pycnogenol In a 2011 study, perimenopausal women who took Pycnogenol for two months experienced statistically significant reductions in hot flashes, night sweats, mood swings, irregular periods, reduced libido, and vaginal dryness.9 For PMS symptoms, a 2008 study found Pycnogenol significantly lowered menstrual pain in those with dysmenorrhea.63 Wild yam Wild yam has a long history of traditional use for menopausal and inflammatory symptoms
Hu Y, Li H, Min J, Yu Y, Liu W, Huang J-W, Zhang L, Yang Y, Dai L, Chen C-C, Guo R-T (2022) Crystal structure and biochemical analysis of the specialized deoxynivalenol-detoxifying glyoxalase SPG from Gossypium hirsutum
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Wound healing properties of a new formulated flavonoid-rich fraction from Dodonaea viscosa Jacq
