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l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women

Animal studies have not reported major toxicity, but the lack of comprehensive human data means risks are unknown467

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This system regulates extracellular glutamate concentrations through non-vesicular release, establishing a vital feedback loop: the released glutamate activates presynaptic group II metabotropic receptors (mGluR2/3), which in turn inhibit vesicular glutamate release and offer protection against N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity (Figure 2) [8,69,70,71]

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