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Pfeuffer and coworkers discovered that in people with an apolipoprotein E genotype, quercetin reduces metabolic parameters, including waist circumference, postprandial blood glucose, and lipids, while increasing inflammatory markers like TNF-., IL-1, IL-10, Caspase-3, Bax/Bcl-2 (241)

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However, limitations include relatively lower resolution for detailed functional nuance compared to ontology-based systems like Gene Ontology, and limited coverage for organisms without well-characterized orthologs

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