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As shown by connected scatterplot in Figure 3 (top-left), the Sucrosomial B12 formulation rapidly raised circulatory vitamin B12 levels above the deficiency threshold, exceeding 300 pg/mL (borderline level) within 24 h (day 1)

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by contrast, U0126, an inhibitor of MAPK kinases, suppressed PFOS-mediated IRE1 overexpression, suggesting that ER stress is a downstream target of the ERK pathway (Fig