Altered histamine receptor expression was also seen for anorexia nervosa and schizophrenia
Animal studies show substantial evidence across stroke models (full functional recovery in spatial memory, motor coordination, balance), Parkinsons models (protection of dopaminergic neurons, near-complete prevention of mortality), multiple sclerosis models (significantly less brain damage), and traumatic brain injury (reduced hemorrhage and edema)
Despite exciting mechanistic and theoretical potential in GLP-1s, we lack human evidence at this point that demonstrates curative effects
Dysfunction of astrocytic connexins 30 and 43 in the medial prefrontal cortex and hippocampus mediates depressive-like behaviours
219,224 It is sometimes prescribed along with tamoxifen, another SERM, which may enhance its effectiveness